Author + information
- Melissa Smith-Parrish,
- Sunkyung Yu,
- Janet Donohue,
- Richard Ohye,
- Edward Bove,
- Mary Best and
- Caren Goldberg
Regional cerebral perfusion (RCP) has been endorsed as a method to improve cerebral protection during neonatal aortic arch reconstruction. However, no human study has demonstrated improvement in developmental outcomes with RCP. We aimed to: 1. Compare early school-age (ESA) neurodevelopmental outcomes among children with single ventricle who underwent the Norwood operation with RCP rather than deep hypothermic circulatory arrest (DHCA), 2. Determine the predictive value of early developmental testing, and 3. Identify additional contributors to ESA development.
Children enrolled in the RCP randomized controlled trial of infants with single ventricle undergoing the Norwood operation with randomization to aortic arch reconstruction with either RCP or DHCA were included. A comprehensive neuropsychological evaluation was performed at ages 5-8 years with this analysis focusing on the Wechsler Intelligence Scales. Additional candidate predictors were investigated as associated with impaired neurodevelopment with chi square and t tests for categorical and continuous variables respectively.
Forty-one patients returned for ESA follow-up. The overall mean full scale IQ was 93.4 ± 18.8 with a mean verbal IQ of 95.9 ± 17.6, a mean performance IQ of 94.5 ± 19.2, and a mean processing speed IQ of 92.5 ± 15.2. There were no statistical differences between the RCP and DHCA groups. The one year Bayley Scale of Infant Development Psychomotor Development Index (r = 0.68, p<0.0001) and Mental Development Index (r = 0.64, p<0.0001) correlated with the full scale IQ at ESA. Participants with lower socioeconomic status (SES) and those without fetal diagnosis had lower IQ scores. However, SES was higher for those with a fetal diagnosis.
Neurodevelopment is delayed after the Norwood operation without an associated improvement with RCP. Bayley Scale of Infant Development scores at 1 year predict ESA measures, though additional unmeasured factors likely explain a significant portion of ESA developmental outcomes. Fetal diagnosis and higher SES are associated with higher IQ scores, but the mechanism remains unclear as SES is higher among those with fetal diagnosis.
Oral Contributions North, Room 121
Saturday, March 09, 2013, 8:00 a.m.-8:15 a.m.
Session Title: Congenital Cardiology Solutions: Pediatric
Abstract Category: 13. Congenital Cardiology Solutions: Pediatric
Presentation Number: 904-3
- 2013 American College of Cardiology Foundation