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We reported the usefulness of the nicorandil (NCR) medication to acute heart failure in prospective randomized study. The purpose of the study was to evaluate the effects of intravenous NCR on hemodynamic according to SBP on admission.
We investigated 123 consecutive patients hospitalized with acute heart failure. Patients were randomly stratified into standard therapy (Control group, n=62) and added NCR therapy to the standard therapy (NCR group, n=61). Furthermore, they were divided into three groups by SBP (Low group, 90≤SBP<120; Intermediate group, 120≤SBP<160; High group, 160≤SBP). We evaluated the values of blood pressure, EF and E/e’ before therapy and after 24 hours, and compared the events of MACE at 60 days between them.
In Low group, there were no significant difference in the change of SBP (ΔSBP; −13±17 vs −8±13) and diastolic blood pressure (DBP) (ΔDBP; −9±11 vs-14±11) between them. The change of pulse pressure significantly increased in NCR group (−4±11 vs 7±12, p< 0.05). The change of E/e’ significantly decreased (1±19 vs-9±17, p< 0.01) and the change of EF significantly increased (2±10 vs-7±10, p< 0.01) in NCR group.
Intravenous administration of NCR for acute heart failure is useful and safe in patients with low blood pressure on admission. The effect of the increase in pulse pressure may be the feature of NCR.
Moderated Poster Contributions
Poster Sessions, Expo North
Saturday, March 09, 2013, 10:00 a.m.-10:45 a.m.
Session Title: Heart Failure: Innovations in Medical Therapy
Abstract Category: 17. Heart Failure: Therapy
Presentation Number: 1133M-265
- 2013 American College of Cardiology Foundation