Author + information
- Krekwit Shinlapawittayatorn,
- Kreokkiat Chinda,
- Siripong Palee,
- Sirirat Surinkaew,
- Kittiya Thunsiri,
- Punate Weerateerangkul,
- Siriporn Chattipakorn,
- Bruce H. KenKnight and
- Nipon Chattipakorn
Right cervical vagus nerve stimulation (VNS) provides cardioprotective effects against acute ischemia-reperfusion injury (IRI) in small animals. We determined whether left cervical (LC) VNS applied either intermittently or continuously imparts cardioprotection against acute IRI in swine.
Thirty-two swine (25–30 kg) were randomized into 4 groups: Control (sham operated, no VNS), Continuous-VNS (C-VNS, 3.5mA, 20Hz), Intermittent-VNS (I-VNS, continuously recurring cycles of 21-s ON, 30-s OFF), and I-VNS+Atropine (1mg/kg). LC VNS was applied immediately after LAD occlusion (60 min), and continued until the end of reperfusion (120 min). The ischemic and non-ischemic myocardium was harvested for cardiac mitochondrial function assessment.
LC VNS significantly reduced infarct size, improved ventricular function, decreased VF episodes, and attenuated cardiac mitochondrial reactive oxygen species production, depolarization and swelling, compared to Control. However, I-VNS produced the most profound cardioprotective effects, particularly infarct size reduction and decreased VF episodes, compared to C-VNS (Figure). These beneficial effects of VNS were abolished by Atropine, suggesting a dominant cholinergic pathway.
During IRI, both C-VNS and I-VNS provide significant cardioprotective effects. However, left I-VNS provides more robust efficacy than left C-VNS with respect to infarct size reduction and reperfusion arrhythmia prevention.
Moderated Poster Contributions
Poster Sessions, Expo North
Saturday, March 09, 2013, 3:45 p.m.-4:30 p.m.
Session Title: Acute Coronary Syndromes: Basic II
Abstract Category: 2. Acute Coronary Syndromes: Basic
Presentation Number: 1169M-174
- 2013 American College of Cardiology Foundation