Author + information
- Jeanine E. Sedjro,
- Javier Cabrera,
- Roomi Nusrat,
- Amay Parikh,
- Nora M. Cosgrove,
- John B. Kostis,
- For the Myocardial Infarction Data Acquisition System (MIDAS) Study Group
Although hypertension and asthma often coexist, it is not known whether asthma in hypertensive patients predicts the occurrence of heart failure (HF), myocardial infarction (Ml) or stroke.
Using the Myocardial Infarction Data Acquisition System (MIDAS), 759 patients were identified with a first admission for hypertension (ICD-9-CM [401–405]) and asthma (ICD-9-CM ). Three controls (n=2,277) matched for age, gender, race, and year of admission were identified for each case with first admission for hypertension but no concurrent or prior history of asthma. The occurrence of HF, Ml and stroke was ascertained for 5 years follow-up.
Patients with asthma (median age 50, IQR [41, 61], 69.2% women, 42.6% Blacks) had a higher risk of developing HF and the combined endpoint of HF, Ml, stroke or death. Similar but more pronounced effects were observed among patients with non-emphysematous Chronic Obstructive Pulmonary Disease.
Hypertensive individuals with asthma have a higher risk of developing HF, the combined endpoint of HF, Ml, stroke and the combined endpoint of HF, Ml, stroke and death in 5 years follow-up compared to those without asthma. This could be related to inflammatory mediators, obesity and the use of beta adrenergic agonists.
|Events #Events||HR*||95% Cl||p-value|
|HF or Death (no censoring)†576||1.24||1.00||1.54||0.0507|
|Combined event of HF, Ml and stroke. 438||1.37||1.08||1.73||0.0081‡|
|Combined event of HF, Ml, stroke and death. 556||1.30||1.06||1.60||0.0108†|
↵* Hazard ratios were adjusted for source of admission, insurance, length of stay, occurrence of diabetes, atrial fibrillation, anemia, renal disease, cancer, disease of the veins, and coronary artery disease during follow-up.
↵† Individuals are allowed to develop other cardiovascular events before HF or Death.
↵‡ Significant p-values.
Poster Sessions, Expo North
Sunday, March 10, 2013, 3:45 p.m.-4:30 p.m.
Session Title: Role of Comorbidities in Heart Failure: From Diabetes, Pulmonary Disease, Hypertension to Atrial Fibrillation
Abstract Category: 15. Heart Failure: Clinical
Presentation Number: 1263-278
- 2013 American College of Cardiology Foundation