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Usefulness of cardiac biomarkers to the patients with heart failure has been widely accepted. Cardiac troponin T (TnT) has been recently applied not only to ischemic heart disease but to heart failure, and recognized as a more accurate marker for heart failure compared to brain natriuretic peptide (BNP). However, hypoxia itself induced by sleep apnea syndrome (SAS) does not increase serum TnT and BNP level among general population with normal cardiac function. The purpose of this study is to evaluate the relationship between cardiac biomarkers and the prevalence of nightly hypoxia using apnea hypopnea index (AHI) in patients with already increased serum TnT due to left ventricular dysfunction caused by ischemic heart disease.
We studied consecutive 26 patients who underwent polysomnography in our institute. They all had left ventricular dysfunction (Ejection Fraction <40%), and blood samples was obtained regarding cardiac TnT.
Cardiac TnT showed significant and strong positive correlation with AHI. Ten patients were treated with continuous positive airway pressure (CPAP). TnT levels significantly decreased after one month CPAP thrapy(Figure).
In patients with left ventricular dysfunction, there is a positive correlation between cardiac biomarkers and AHI. TnT significantly decreased following CPAP.
These results may support the usefulness of cardiac biomarkers for the treatment of SAS in patients with left ventricular dysfunction.
Poster Sessions, Expo North
Sunday, March 10, 2013, 3:45 p.m.-4:30 p.m.
Session Title: Role of Comorbidities in Heart Failure: From Diabetes, Pulmonary Disease, Hypertension to Atrial Fibrillation
Abstract Category: 15. Heart Failure: Clinical
Presentation Number: 1263-279
- 2013 American College of Cardiology Foundation