Author + information
- Prateeti Khazanie,
- Li Liang,
- Laura Qualls,
- Lesley Curtis,
- Gregg Fonarow,
- Bradley Hammill,
- Stephen Hammill,
- Paul Heidenreich,
- Frederick Masoudi,
- Adrian Hernandez and
- Jonathan Piccini
Atrial fibrillation (AF) is common among patients hospitalized with heart failure (HF). The associations of preexisting and new-onset AF with long-term outcomes are unclear.
We analyzed 27,829 HF admissions from 2006-2008 at 281 hospitals participating in the American Heart Association's Get With The Guidelines-HF program linked with Medicare claims. Patients were classified as having preexisting, new-onset, or no AF. We used Cox proportional hazards models to identify factors that were independently associated with all-cause mortality, all-cause readmission, and readmission for HF or stroke at 1 and 3 yrs.
After multivariable adjustment, preexisting AF was associated with greater 3 yr risks of all-cause mortality (hazard ratio, 1.14; 99% confidence intervals, 1.08-1.20), all-cause readmission (1.09; 1.05-1.14), HF readmission (1.15; 1.08-1.21), and stroke readmission (1.20; 1.01-1.41), compared with no AF. There was also a greater hazard of mortality at 1 yr among patients with new-onset AF (1.12; 1.01-1.24). The cumulative incidence curves for mortality are shown in the Figure. New-onset AF was not associated with a greater risk of the readmission outcomes compared to no AF.
AF is common among patients hospitalized with HF. Both preexisting and new-onset AF were associated with greater long-term mortality among older patients with HF. Preexisting AF was associated with greater risk of readmission.
Poster Sessions, Expo North
Sunday, March 10, 2013, 3:45 p.m.-4:30 p.m.
Session Title: Role of Comorbidities in Heart Failure: From Diabetes, Pulmonary Disease, Hypertension to Atrial Fibrillation
Abstract Category: 15. Heart Failure: Clinical
Presentation Number: 1263-285
- 2013 American College of Cardiology Foundation