Author + information
- Konstantinos P. Tsioufis,
- Vasilios Papademetriou,
- Dimitrios Tsiachris,
- Kyriakos Dimitriadis,
- Costas Thomopoulos,
- Alexandros Kasiakogias,
- Athanasios Kordalis,
- Dimitrios Tousoulis,
- Ioannis Kallikazaros and
- Christodoulos Stefanadis
Transluminal renal sympathetic denervation (RSD) reduces blood pressure (BP) in patients with treatment-resistant hypertension. We assessed the effect of RSD on indexes of heart rate variability (HRV) in patients with resistant hypertension.
Fourteen patients with resistant hypertension underwent ambulatory BP measurements and Holter monitoring at baseline and 1 month after RSD using the EnligHTN ablation catheter (St. Jude Medical, CA, USA). SyneScope analysis system calculated the recommended time- and frequency-domain parameters of HRV.
One month post RSD, office and 24-hour BP was significantly reduced by 38/14.1 mmHg, p<0.001/0.003 and 18/9.5 mmHg, p30 and >50 ms, respectively) marginally lost significance during daytime period of Holter monitoring. Frequency domain indexes, total power, very low frequency, low frequency (HF) and high frequency (HF) were significantly increased, while the decrease in the LF/HF ratio just missed statistical significance. Moreover, the increase in LF and HF was sustained both during the daytime and nighttime periods. No relationship was evident between the difference in time and frequency domain HRV parameters after RSD and the drop in office and 24 hour BP.
RSD significantly reduces office and ambulatory BP and restores autonomic balance in patients with resistant hypertension, suggesting the presence of “pleotropic” effects of RSD beyond the BP reduction in this setting.
Poster Sessions, Expo North
Sunday, March 10, 2013, 3:45 p.m.-4:30 p.m.
Session Title: Role of Comorbidities in Heart Failure: From Diabetes, Pulmonary Disease, Hypertension to Atrial Fibrillation
Abstract Category: 15. Heart Failure: Clinical
Presentation Number: 1263-288
- 2013 American College of Cardiology Foundation