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Platelet abnormalities have been well described in advanced heart failure patients. Two platelet markers have been gaining importance in the recent past; mean platelet volume (MPV) and platelet to lymphocyte ratio (PLR). MPV has shown to predict short term mortality in acute heart failure, but PLR has not been studied so far in heart failure.
We reviewed 551 consecutive patients with advanced heart failure who underwent transplant evaluation between 2007 and 2010. Patients were divided into tertiles based on MPV and also divided into three groups based on PLR (<150, 150-300, >300; cutoffs obtained from previously published studies). Survival (death or heart transplant) analysis was assessed by Kaplan-Meier curves and multivariate Cox proportional hazard regression.
Mortality/transplant rates decreased with increasing tertiles of MPV (54% vs. 50.5% vs. 47.6%) in our cohort, but there was no statistical significance (p=0.35). Mortality/transplant rates increased with increasing PLR groups (45.7% vs. 54.5% vs. 59.4%, p = 0.16). But in cox proportional analysis, neither PLR nor MPV remained as an independent predictor of mortality.
Although platelet markers are currently becoming popular, neither MPV nor PLR independently predicted mortality in our cohort of stage D heart failure patients.
Poster Sessions, Expo North
Sunday, March 10, 2013, 3:45 p.m.-4:30 p.m.
Session Title: New Paradigms in Prognostic Role of Biomarkers in Heart Failure
Abstract Category: 15. Heart Failure: Clinical
Presentation Number: 1265-299
- 2013 American College of Cardiology Foundation