Author + information
- Lakshmana Pendyala,
- Rebecca Torguson,
- Joshua Loh,
- Hironori Kitabata,
- Sa'ar Minha,
- Salem Badr,
- Danny Dvir,
- Israel Barbash,
- Lowell Satler,
- Augusto Pichard and
- Ron Waksman
Women undergoing percutaneous coronary intervention (PCI) have higher adverse outcomes than men. The present study aimed to determine differences in correlates between genders for long-term outcomes in acute coronary syndrome (ACS).
The study included a cohort of 6929 consecutive patients who presented with ACS. Major adverse cardiovascular events (MACE), defined as all-cause mortality, myocardial infarction, and target lesion revascularization at 1-year follow-up. Independent correlates of adverse outcomes for each gender were identified using multivariable proportional hazard regression analysis.
Compared to males, female patients were older (p <0.001), had a higher prevalence of diabetes mellitus (p <0.001), hypertension (p <0.001), chronic renal insufficiency (p=0.02), peripheral arterial disease (p <0.001), congestive heart failure (p <0.001, and higher body mass index (p <0.001). ACS presentation in Women tends to be unstable angina while men have more acute MI. At 1 year, the rates of all-cause mortality (11% vs. 7.5%, p <0.001) and MACE (16% vs. 13%, p <0.001) were higher in Women. There is a stark gender disparity for the independent correlates of mortality and MACE at 1 year (Fig). Moreover, the traditional correlates do not have the same impact in women as they do in men.
There are different correlates for adverse PCI outcomes across genders. These correlates should be taken into account when subjecting women to contemporary PCI.
Poster Sessions, Expo North
Saturday, March 09, 2013, 3:45 p.m.-4:30 p.m.
Session Title: Gender, Dissection, Outcomes from ACS
Abstract Category: 1. Acute Coronary Syndromes: Clinical
Presentation Number: 1170-194
- 2013 American College of Cardiology Foundation