Author + information
- JinWei Tian,
- Sining Hu,
- Haibo Jia,
- Farhad Abtahian,
- Koji Kato,
- Taishi Yonetsu,
- Rocco Vergallo,
- Iris McNulty,
- Shaosong Zhang,
- Bo Yu and
- Ik-Kyung Jang
Although the incidence of ACS increases in women in their 50's and 60's, the differences in culprit lesion characteristics between men and woman have not been well studied.
We evaluated 401 consecutive patients with ACS who underwent OCT prior to coronary intervention. The fibrous cap thickness, lipid core arc, and lipid core length of the culprit lesion were measured. Target lesions were also evaluated for the presence of plaque rupture and thrombus.
Women were older than men (61±8 years vs. 57±11 years, p=0.001) but less likely to be smokers (56.2% vs. 56.2%, p<0.001). OCT analysis showed no significant differences in fibrous cap thickness (72.7±37.8 µm vs. 68.4±35.5 µm, p=0.32), lipid core arc (198.3±78.1° vs. 189.8±91.5°, p=0.40), and lipid core length (18.2±8.87 cm vs. 18.9 ±8.09 cm, p=0.52). There was also no difference in the frequency of thin cap fibroatheroma and plaque rupture (p = 0.70 and p=0.32, respectively). However, thrombus was less frequent in women than in men (17.6% vs. 35.8%, p = 0.001). After adjustment for age, there were no significant differences in plaque characteristics between the two groups.
The culprit lesion characteristics in patients with ACS are similar between men and women but thrombus is more common in men.
Poster Sessions, Expo North
Saturday, March 09, 2013, 3:45 p.m.-4:30 p.m.
Session Title: Gender, Dissection, Outcomes from ACS
Abstract Category: 1. Acute Coronary Syndromes: Clinical
Presentation Number: 1170-195
- 2013 American College of Cardiology Foundation