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Little is known about the effect of a low platelet count (PC) on mortality of patients (pts) with systolic heart failure (SHF). The aim of this study was to determine the prognostic value of thrombocytopenia (TMPA) in SHF pts by assessing all-cause mortality and hospital readmission rates.
2705 SHF pts, defined by an ejection fraction ≤40% on echo, were assessed in this study. All pts were receiving beta-blocker, ACE-inhibitor, and statin therapy. Pts were grouped based on PCs measured within one month of diagnosis.
Group A: SHF + normal PC >140K
Group B: SHF + PC 100K to 140K
Group C: SHF + PC 70K to 100K
Group D: SHF + PC <70K
Inpatient and social security death records were used to determine one-year mortality in all pts. Hospital records were reviewed to determine sixty-day readmission rate for congestive heart failure exacerbation.
Mean age of pts was 65.5 ± 15.5 years (62% male). TMPA was associated with a higher relative risk (RR) for one-year mortality in groups B (RR 1.57; 95% confidence interval [CI] 1.28-1.93), C (RR 2.27; 95% CI 1.74-2.96), and D (RR 2.33; 95% CI 1.62-3.37) compared to Group A. TMPA also conferred higher RR for readmission in groups B (RR 1.26; 95% CI 1.13-1.41), C (RR 1.20; 95% CI 1.01-1.42), and D (RR 1.63; 95% CI 1.32-2.02).
This study demonstrates that the severity of TMPA in pts with SHF correlates with higher mortality and hospital readmission. These findings may support the use of PCs as a prognostic tool in the assessment of the SHF patient.
Poster Sessions, Expo North
Monday, March 11, 2013, 9:45 a.m.-10:30 a.m.
Session Title: Epidemiology, Risk Modeling and Prediction of Outcomes in Heart Failure
Abstract Category: 15. Heart Failure: Clinical
Presentation Number: 1308-300
- 2013 American College of Cardiology Foundation