Author + information
- M Chadi Alraies,
- Wael AlJaroudi,
- Muhammad Tariq,
- Deborah Kwon,
- Kathleen Husbands,
- Brian P. Griffin and
- Allan L. Klein
Recurrent pericarditis (RP) is a common complication of acute pericarditis, with 30% recurrence after first attack. Steroids are associated with increased recurrence of pericarditis with known major side effects. Cardiac MR (CMR) has been used to assess inflammation and management. The aim of study is to assess the role of CMR-guided therapy in RP compare to standard therapy.
Method and Results
We evaluated 570 consecutive patients who developed recurrence following the first attack of pericarditis who were all treated with colchicine and NSAIDs as first treatment. 250 patients treated with medications without CMR (group 1), and 257 patients had CMR-guided therapy (group 2). Both groups had similar baseline characteristics (Table 1), and with similar follow-up period. (Table 1). Patients in group 1 had higher number of steroid pulse therapy (p= 0.003) (defined as prednisone 50 mg orally daily for 10 days then tapered over 4 weeks), and higher overall total milligram of steroid administered as compared to those in group 2 (p= 0.001). Recurrence rate and pericaridocentesis were lower in group 2 as well (p<0.0001). There was no difference in incidence of constrictive pericarditis, or pericardiectomy among groups
CMR-guided therapy modulates the management of recurrent pericarditis, which can decrease recurrence rate and the exposure to steroids. Larger prospective randomized multicenter study is necessary to validate these findings.
Poster Sessions, Expo North
Saturday, March 09, 2013, 10:00 a.m.-10:45 a.m.
Session Title: Imaging: MRI I Prognostic Value of CMR
Abstract Category: 19. Imaging: MRI
Presentation Number: 1137-319
- 2013 American College of Cardiology Foundation