Author + information
- Mazurek Tomasz,
- Kobylecka Malgorzata,
- Wilimski Radoslaw,
- Kochman Janusz,
- Filipiak Krzysztof,
- Krolicki Leszek and
- Opolski Grzegorz
Perivascular adipose tissue (PVAT) in overweight patients may adversely influence coronary lesion formation and plaque stability through the augmented local inflammatory burden. Maximal standardized uptake value (SUV) of 18-FDG detected by PET is proportional to macrophage density. We sought to examine PVAT thickness (TH) and inflammatory activity (SUV) in patients with stable coronary artery disease (CAD).
15 lean and 20 overweight (BMI>25) consecutive patients, with confirmed CAD underwent FDG-PET/CT. TH was measured in two perpendicular dimensions on axial cuts separately for each artery. SUV was measured in fat surrounding coronaries (RCA, LCX, LAD), subcutaneous fat (SC), visceral thoracic fat (VS) and epicardial fat over right ventricle (EPI). Similar measurements were taken in healthy volunteers matched for age and BMI (n=17). In CAD group associations of SUV with traditional risk factors were further analyzed. Extent of CAD was determined by % stenosis using QCA in segments corresponding to PET/CT sections.
PVAT SUV was greater than SUV in other fat locations for all groups (SC: 0.27; VS: 0.54; EPI: 0.59; RCA SUV: 1.11; LCX SUV: 1.26; LAD SUV: 1.30; p<.0001; ANOVA). There was no difference in TH between CAD and controls, but SUV was significantly greater in CAD than in controls in all fat locations (RCA SUV: 1.34 vs 0.62, p<.0001; LCX SUV: 1.53 vs 0.71, p<.0001; LAD SUV: 1.58 vs 0.71, p<.0001; SC SUV: 0.30 vs 0.19, p<.001; VS SUV: 0.60 vs 0.41, p<.001; EPI SUV: 0.67 vs 0.43, p<.001). PVAT SUV was not related to gender, age, BMI or serum glucose. Finally, PVAT SUV was positively related to % stenosis of respective coronary artery (RCA: 0.50; p<.03; LCX 0.59; p<.006; LAD 0.73 p<.0002), but only if BMI>25. In univariate and multivariate models correlations between PVAT SUV and % stenosis were independent of history of hypertension, myocardial infarction, dyslipidemia, smoking, diabetes and fasting glucose.
1. Inflammatory activity of PVAT, not its amount is higher in CAD patients, than in non-CAD controls; 2. Inflammatory activity of PVAT is greater than in SC, VS, or EPI; 3. In overweight patients PVAT SUV independently correlates with the extent of CAD.
Poster Sessions, Expo North
Saturday, March 09, 2013, 10:00 a.m.-10:45 a.m.
Session Title: Cardiac PET: Towards Flow Quantification and Novel Applications
Abstract Category: 21. Imaging: Nuclear
Presentation Number: 1139-328
- 2013 American College of Cardiology Foundation