Author + information
- Seth Uretsky,
- Alan Rozanski,
- Azhar Supariwala,
- Subu Nair,
- Randy Cohen,
- Srinivasa Gurram,
- Sri Lakshmi Kala Bonda,
- Prema Bezwada,
- Naganath Thota,
- Seema Manchireddy,
- M. Robert Peters and
- Steven Wolff
Invasive angiography and post mortem studies have shown that while age is a strong predictor for the presence of CAD, young patients often have CAD. We assessed the relationship between CAD risk factor burden and the prevalence, severity, and morphology of CAD in young patients.
Our study includes 729 (44 ± 6.8 yrs, male 62%) pts referred for coronary CT angiography (CCTA). Young age was defined as men ≤ 50 yrs and females ≤55 yrs. Baseline clinical and demographic data were collected at time of study. The prevalence, morphology, and severity of each plaque were defined.
Among the 729 pts included in this study, 10% had no CAD risk factors, 59% had 1-2 risk factors, and 32% had ≥3 risk fators. 50% of patients had either chest pain or shortness of breath. The mean calcium score was 30 ± 104. There were 746 coronary plaques in 272 (36%) pts. The majority of plaques were calcified (42%) or mixed (41%). 54 (7%) pts had a stenosis ≥50% percent; and 10% of pts with a CAC score = 0 had plaque on CCTA. On adjusted multivariate analysis, age (HR = 1.1, p<0.0001), males (HR=4.8, p<0.0001), smoking (HR=1.4, p=0.3, and family history (HR=1.6, p=0.004) were associated with the presence of CAD on CCTA.
In young pts, mean CAC scores are low, but more than 1/3rd had the presence of coronary plaques. There was a low prevalence of non-calcified plaques and stenoses >50%. Notably, the risk factor burden had a significant effect on the likelihood of observing higher CAC scores, plaques on CCTA, and stenoses of ≥50%.
Poster Sessions, Expo North
Saturday, March 09, 2013, 10:00 a.m.-10:45 a.m.
Session Title: Imaging: CT/Multimodality I
Abstract Category: 20. Imaging: CT/Multimodality
Presentation Number: 1140-336
- 2013 American College of Cardiology Foundation