Author + information
- Usman Khokhar,
- Anum Aslam,
- Ammar Chaudhry,
- Alexander Abramowicz,
- Michael Cortegiano,
- Michael Poon and
- Szilard Voros
We have previously shown that 0.5 mm isotropic reconstructions of coronary artery calcium (CAC) scans detect more subclinical atherosclerosis compared to standard 3.0 mm reconstructions; however, comparison to CT angiography has not been performed previously.
In this prospective study, we quantified CAC in 104 patient using non-contrast enhanced scans with 0.5 mm isotropic and 3.0 mm standard reconstructions (acquisition parameters: 320- MDCT, volumetric mode, prospective EKG triggering). Agatston score at 0.5 and 3.0 mm reconstruction was determined by two observers. Clinically indicated CTA was also performed on the same patients; CAC findings were compared to CTA. Chi-square test was performed for comparison.
Mean age was 54 ± 12 years; 50% were male. More patients with subclinical atherosclerosis were detected on 0.5 mm vs. 3.0 mm reconstructions (76.9% vs. 53.8%, p<0.0001; Table). Subclinical atherosclerosis was detected on CTA in 54.8%; importantly, in 23 patients (22.1%), 0.5 mm isotropic CAC detected subclinical atherosclerosis, while 3.0 mm CAC and CTA did not.
Isotropic, 0.5 mm reconstruction of non-contrast-enhanced CT detected 23.1% and 22.1% more patients with subclinical atherosclerosis, compared to standard, 3.0 mm CAC scans and CTA scans, respectively. Therefore, 0.5 mm CAC scans may be more sensitive for the detection of subclinical atherosclerosis; its potential clinical utility needs to be validated in large, prospective studies.
|Negative for Subclinical Atherosclerosis||Positive for Subclinical Atherosclerosis||Chi-Square test||p-value|
|CAC 0.5 mm Reconstruction||24 (23.1%)||80 (76.9%)|
|CAC 3.0 mm Reconstruction||48 (46.2%)||56 (53.8%)||33.64||p<0.0001|
|Coronary CTA||47 (45.2%)||57 (54.8%)||35.02||p<0.0001|
Poster Sessions, Expo North
Saturday, March 09, 2013, 10:00 a.m.-10:45 a.m.
Session Title: Imaging: CT/Multimodality II
Abstract Category: 20. Imaging: CT/Multimodality
Presentation Number: 1141-339
- 2013 American College of Cardiology Foundation