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Noninvasive assessment of coronary plaque is important for coronary risk stratification. But the utility of 64-slice CT remains unclear for evaluation of coronary plaque component. Recently high definition computed tomography (HDCT) with new gemstone detector has been developed, which has high spatial resolution.
We enrolled consecutive 33 patients with unstable angina pectoris (UAP) or stable angina pectoris (SAP). We evaluated noncalcified coronary plaque and classified as lipid (−42 to 60 HU: Hounsfield unit), fibrous (61 to 112 HU) or calcified (>500 HU). We assessed MLA, %stenosis, percentage of lipid volume (%lipid) and percentage of fibrous volume (%fibrous) in UAP, which were compared to SAP.
A total 38 culprit lesion was evaluated (16 lesions in UAP). Culprit lesions with UAP were not different in MLA (2.3±0.5mm vs 2.7±1.0mm, p=0.10) and %stenosis (68.2±8.2% vs 64.2±14.4%, p=0.17), but showed a significant increase in %lipid (60.16±7.71% vs 49.46±10.13%, P<0.01) and a significant decrease in %fibrous (34.28±8.19% vs 41.40±11.92%, P<0.05) compared to those with SAP.
Culprit lesions with UAP patients are associated with vulnerable plaque. HDCT with new gemstone could be a useful approach for the noninvasive assessment of plaque characteristics and may contribute to coronary risk stratification.
Poster Sessions, Expo North
Saturday, March 09, 2013, 10:00 a.m.-10:45 a.m.
Session Title: Imaging: CT/Multimodality II
Abstract Category: 20. Imaging: CT/Multimodality
Presentation Number: 1141-340
- 2013 American College of Cardiology Foundation