Author + information
- Casper N. Bang,
- Mary Roman,
- Lyle Best,
- Elisa Lee,
- Barbara Howard,
- Giovanni de Simone,
- Peter Okin,
- Lars Kober,
- Kristian Wachtell and
- Richard Devereux
Left ventricular (LV) hypertrophy (LVH) is traditionally classified as concentric or eccentric based on LV relative wall thickness. We evaluated the prognostic value of a 4-group LVH classification based on LV dilatation (high LV end-diastolic volume [EDV] index and concentricity (mass/EDV [M/EDV](2/3)) in a population-based sample.
3178 American Indian participants with measurable LV mass were followed for a mean of 11.5 years. 931 with LVH (LV mass/height2.7 ≥49 g/m2.7 in men, ≥45 g/m2.7 in women) were divided into 4 groups; “eccentric non-dilated” (normal M/EDV [≤8.1 g/mL (women), ≤9.1 g/mL (men)] and EDV [<76 ml/m2]), “eccentric dilated” (high EDV, normal M/EDV), “concentric non-dilated” (high M/EDV, normal EDV), “concentric dilated” (high M/EDV and EDV).
At baseline, LVs were categorized as “eccentric non-dilated” in 19.3%, “eccentric dilated” in 5.6%, “concentric non-dilated” in 3.6%, “concentric dilated” in 0.5% and non-LVH in 70.7%. In Cox analyses adjusting for age, sex, diabetes and BMI, compared to the no LVH group, the eccentric non-dilated and both groups of concentric LVH had higher risk of all-cause mortality regardless of dilatation and baseline differences whereas the eccentric dilated group did not (Figure).
In a population-based sample of American Indians with high prevalences of obesity and diabetes, participants with eccentric non-dilated LVH and concentric LVH with or without LV dilatation had high risk of all-cause mortality.
Poster Sessions, Expo North
Saturday, March 09, 2013, 10:00 a.m.-10:45 a.m.
Session Title: Imaging: LV Systolic Function
Abstract Category: 18. Imaging: Echo
Presentation Number: 1142-351
- 2013 American College of Cardiology Foundation