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The short deceleration time (DT) (“constrictive-restrictive”) E-wave pattern is due to increased chamber stiffness, while prolonged E-wave deceleration time is due to ‘delayed relaxation'. Therefore, stiffness and relaxation are DT determinants. DT has been expressed algebraically as a function of stiffness only. Subsequent analysis of E-waves via the parametrized diastolic filling (PDF) formalism revealed that DT is an algebraic function of both stiffness and relaxation.
We hypothesize that E-wave analysis via PDF permits decomposition of DT into stiffness (DTs) and relaxation (DTr) components (DT = DTs + DTr), reflecting diastatic chamber stiffness (K, slope of diastatic pressure-volume relation), and relaxation (⊠, isovolumic time-constant) effects. For validation, simultaneous (conductance catheter) pressure-volume (P-V) and E-wave data from 12 control subjects, normal (>50%) LV ejection fraction, and 4 with delayed relaxation (DT>220 msec) were analyzed. PDF analysis of each E-wave provided DTs and DTr.
For all 16 subjects (27 beats/subject, 430 beats total) linear regression yielded DTs = α K + β (R2 = 0.72) where α = −0.37 and β = 0.19, and DTr = m?+ b (R2 = 0.89) where m = 2.49 and b = −0.10.
E-wave DT consists of stiffness (DTs) and relaxation (DTr) components that are determined by diastatic chamber stiffness (K) and relaxation (?) respectively.
Poster Sessions, Expo North
Saturday, March 09, 2013, 10:00 a.m.-10:45 a.m.
Session Title: Imaging: LV Diastolic Function
Abstract Category: 18. Imaging: Echo
Presentation Number: 1143-357
- 2013 American College of Cardiology Foundation