Author + information
- Aju Pazhenkottil,
- René Nkoulou,
- Mathias Wolfrum,
- Silke Kuest,
- Jelena Ghadri,
- Michael Fiechter,
- Ronny Buechel,
- Bernhard Herzog,
- Oliver Gaemperli and
- Philipp Kaufmann
New generation of gamma camera (CZT) allows ultrafast MPI and whole heart acquisition with non-rotating collimators positioned around the patient's chest. We validated left ventricular (LV) end diastolic volume (EDV), end systolic volume (ESV) and ejection fraction (EF) assessed at low dobutamine dose (LD) and high dose during peak stress (HD) by real-time gated-SPECT myocardial perfusion imaging (MPI) on a Cadmium-Zinc-Telluride (CZT) gamma camera using cardiac magnetic resonance imaging (CMR) as standard of reference.
After injecting 99mTc-tetrofosmin (320 MBq) in 50 patients (mean age 64 +/- 11 years) EDV, ESV, EF, LV wall motion (LVWM) and thickening (LVWT) were assessed at rest, at LD/HD and post-stress by CZT gated-SPECT MPI and by CMR (n= 20). Changes in SPECT EF at HD and post-stress were compared to CMR, where 5% change was considered clinically relevant.
Mean EF from CZT was 49±15% at rest, 62±18% at HD, and 56±17% post-stress (p< 0.001 vs rest and HD). The correlation between rest studies with CZT and CMR was excellent for EF (r=0.96; Bland-Altman limits of agreement: +0 to 14.8%), EDV (r=0.91; +0 mL to +86 mL) and ESV (r=0.96; −14 mL to +34 mL). Agreement in EF between HD CMR and immediate post-stress CZT (reflecting standard acquisition using conventional SPECT camera unable to scan during stress) was 45%, while this increased to 85% with real-time HD CZT scan.
The very short scan time of the ultrafast CZT SPECT MPI scanning allows real-time assessment of EF and regional wall motion evaluation during incremental dobutamine stress levels, adding clinical information to MPI scanning.
Poster Sessions, Expo North
Saturday, March 09, 2013, 3:45 p.m.-4:30 p.m.
Session Title: Nuclear Imaging: Looking Beyond Perfusion
Abstract Category: 21. Imaging: Nuclear
Presentation Number: 1183-356
- 2013 American College of Cardiology Foundation