Author + information
- Eduardo Pozo,
- Ines Garcia-Lunar,
- Pablo Pazos,
- Claudia Calcagno,
- Sarayu Ramachandran,
- Charles Adapoe,
- Ajith Nair,
- Adam Jacobi,
- Valentin Fuster and
- Javier Sanz
Pulmonary hypertension (PH) leads to progressive right ventricular (RV) failure. Post-contrast T1 mapping with cardiac magnetic resonance (CMR) has been validated for the quantification of myocardial extracellular volume, a surrogate of diffuse interstitial fibrosis. We aimed at evaluating the presence of septal fibrosis in PH patients with T1-mapping and its potential associations with RV performance and hemodynamic status.
38 patients with known or suspected PH of various etiologies underwent 3-T CMR. Septal T1 time was quantified from a Look-Locker sequence acquired 5-15 minutes after gadolinium infusion (0.19±0.01 mmol/Kg). All patients underwent right heart catheterization within 100 days of CMR. Septal T1 times were correlated with CMR-derived RV volumes and ejection fraction (RVEF), and cardiac output, mean pulmonary pressure (mPAP), and vascular resistance obtained invasively.
The mean age was 55.4±14.1 years and 44.7% of the patients were males. PH (mPAP>25 mmHg) was present in 60.5%. Shorter septal T1 times were found in patients with greater PH and RV failure severity (Table 1).
A reduction in post-contrast septal T1 times, possibly indicating increased interstitial fibrosis, correlates well with RV structural and functional impairment and hemodynamic severity in PH. T1-mapping may constitute a novel approach for the evaluation of cardiac adaptation to pressure overload.
Poster Sessions, Expo North
Saturday, March 09, 2013, 3:45 p.m.-4:30 p.m.
Session Title: Imaging: MRI III – CMR in Myocardial Disease and Dysfunction
Abstract Category: 19. Imaging: MRI
Presentation Number: 1184-371
- 2013 American College of Cardiology Foundation