Author + information
- Yeonyee Elizabeth Yoon,
- Sung-Ai Kim,
- Kyoung-Ha Park,
- Seong Hwan Kim,
- Jae-Hyeong Park,
- Seung-Pyo Lee,
- Hyung-Kwan Kim,
- Yong-Jin Kim,
- Dae-Won Sohn and
- Goo-Yeong Cho
Paroxysmal atrial fibrillation (AF) frequently progresses to persistent/permanent AF. We investigated echocardiographic predictors of AF progression.
We conducted a multicenter, prospective, observational study and included 313 paroxysmal AF patients with 2D speckle tracking echocardiography. LA diameter, volume, and mechanical function were estimated. The ratio of E/e’ to global LA strain was used as an index of LA stiffness.
Progression of AF to persistent/permanent stage occurred in 52 (17%) patients (median follow-up, 26 months). LA diameter, volume index, expansion index, active emptying fraction and LA stiffness index were significant predictors for AF progression. LA diameter ≥40mm and volume index ≥34.3ml/m2 were associated with hazard increase for AF progression (HR, 2.0 and 2.6; p=0.016 and 0.001). LA stiffness index ≥0.34 was associated 2.8-fold hazard increase for AF progression (HR, 2.8; p=0.001). In a subgroup with a LA volume index <34.3ml/m2, patients with LA stiffness index ≥0.34 had significantly worse event-free survival (p=0.006). However, in a subgroup with a LA volume index ≥34.3ml/m2, event-free survival was not significantly different by LA stiffness index (p=0.281).
Echocardiographic measure of LA diameter, volume, and mechanical function, including LA stiffness were associated with AF progression. LA stiffness could provide additional prognostic information in patients with paroxysmal AF but with normal LA volume.
Poster Sessions, Expo North
Sunday, March 10, 2013, 9:45 a.m.-10:30 a.m.
Session Title: Imaging: Echo: Atrial Imaging
Abstract Category: 18. Imaging: Echo
Presentation Number: 1226-332
- 2013 American College of Cardiology Foundation