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Both Left atrial appendage flow velocity (LAAFV) and CHA2DS2-VASc score are associated with thromboembolic risk. Left atrial strain (LAs) is a novel parameter of LA function. However, little is known about the impact of LAs on stroke risk stratification. In this study, we examined the relationship among CHA2DS2-VASc score, LAAFV and LAs.
We studied 62 consecutive patients (age: 64±12, 44 males) who underwent transesophageal echocardiography for evaluation of LAA thrombus. LAs was assessed by averaging segments measured in the 4- and 2-chamber views by transthoracic echocardiography. Patients with more than mild valvular heart disease were excluded.
Thirty six patients showed sinus rhythm (58%) and 26 atrial arrhythmia (42%). Both LAs (21.1±9.9%) and LAAFV (50±31cm/s) were significantly associated with CHA2DS2-VASc score (2.4±1.6) (r=-0.414, p=0.001; r=-0.272, p=0.032, respectively). After adjusting with age, gender and LAAFV, LAs was significantly and independently associated with CHA2DS2-VASc (β=-0.33, p=0.002). Finally, In multivariate regression analysis of the factors used in CHA2DS2-VASc scoring, age and CHF were independently associated with LAs (β=-0.24, p=0.034; β=-0.47, p<0.001, respectively).
LAs was significantly and independently correlated with CHA2DS2-VASc score, suggesting that LAs serves as a functional predictor for future cardioembolic stroke irrespective of LAAFV.
Poster Sessions, Expo North
Sunday, March 10, 2013, 9:45 a.m.-10:30 a.m.
Session Title: Imaging: Echo IX
Abstract Category: 18. Imaging: Echo
Presentation Number: 1227-344
- 2013 American College of Cardiology Foundation