Author + information
- Kunal Bhatt,
- Wassim Odeh,
- Parag Joshi,
- Reynaria Pitts,
- Zhen Qian,
- Nancy Flockhart,
- Viju Varghese,
- James Lee,
- Russ Warnick,
- Mohmed Ashmaig,
- Szilard Voros,
- Joseph Miller and
- Sarah Rinehart
Apolipoprotein B (apoB) is an excellent risk predictor for cardiovascular events, but little is known about the intestinal apoB48 subtype compared with the hepatic apoB100 subtype. Coronary artery calcium (CAC) is an extremely specific tool to quantify subclinical atherosclerosis. This study aimed to evaluate the association between apoB subtypes and CAC.
We prospectively enrolled intermediate-risk, asymptomatic subjects and measured lipid biomarkers and CAC, from which we calculated age/gender/ethnicity-specific population percentile from the Multi-Ethnic Study of Atherosclerosis (MESA). MESA percentile >75th, suggesting relatively advanced atherosclerosis, was used to evaluate associations with lipid indices. We performed multivariate analysis (adjusted for smoking, hypertension, diabetes and statin use) to determine odds ratio for MESA > 75%.
From 71 patients (mean 63.3 years, 96% men) with mean Framingham Risk Score of 14%, 20 (28.2%) had MESA > 75%. ApoB100 was found to have the highest association with MESA > 75% (OR 1.53, 95% Cl 1.063-2.21, p=0.022) (Figure). Other lipid markers, except for total apoB, were not found to be significant independent risk factors.
In this group of intermediate risk patients, increasing apoB100 is predictive of CAC > 75th MESA percentile. Future studies are necessary to determine whether apoB100 can improve cardiovascular risk prediction models.
Poster Sessions, Expo North
Sunday, March 10, 2013, 9:45 a.m.-10:30 a.m.
Session Title: Imaging: CT/Multimodality VI
Abstract Category: 20. Imaging: CT/Multimodality
Presentation Number: 1230-369
- 2013 American College of Cardiology Foundation