Author + information
- Received June 27, 2012
- Revision received August 7, 2012
- Accepted August 21, 2012
- Published online March 19, 2013.
- Philippe Généreux, MD⁎,†,‡,
- Stuart J. Head, MSc§,
- Rebecca Hahn, MD⁎,†,
- Benoit Daneault, MD⁎,†,
- Susheel Kodali, MD⁎,†,
- Mathew R. Williams, MD⁎,†,
- Nicolas M. van Mieghem, MD∥,
- Maria C. Alu, MM⁎,
- Patrick W. Serruys, MD, PhD∥,
- A. Pieter Kappetein, MD, PhD§ and
- Martin B. Leon, MD⁎,†,⁎ ()
- ↵⁎Reprint requests and correspondence:
Dr. Martin B. Leon, Columbia University Medical Center, New York-Presbyterian Hospital, 177 Fort Washington Avenue, New York, New York 10032
Paravalvular leak (PVL) is a frequent complication of transcatheter aortic valve replacement (TAVR) and is seen at a much higher rate after TAVR than after conventional surgical aortic valve replacement. Recent reports indicating that PVL may be correlated with increased late mortality have raised concerns. However, the heterogeneity of methods for assessing and quantifying PVL, and lack of consistency in the timing of such assessments, is a hindrance to understanding its true prevalence, severity, and effect. This literature review is an effort to consolidate current knowledge in this area to better understand the prevalence, progression, and impact of post-TAVR PVL and to help direct future efforts regarding the assessment, prevention, and treatment of this troublesome complication.
Dr. Généreux has received speaker honoraria, consulting fees, and research grants from Edwards Lifesciences. Dr. Kodali has received consulting fees from Edwards Lifesciences and St. Jude Medical. Dr. Kappetein is member of a steering committee of the SURTAVI (Surgical Replacement and Transcatheter Aortic Valve Implantation) trial sponsored by Medtronic. Dr. Leon is a nonpaid member of the scientific advisory board of Edwards Lifesciences. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose. Drs. Généreux and Head are joint first authors.
- Received June 27, 2012.
- Revision received August 7, 2012.
- Accepted August 21, 2012.
- American College of Cardiology Foundation