|Model 1: Clinical Risk Score⁎||Model 2: Clinical Risk Score + CAC||Model 3: Clinical Risk Score + CFR||Model 5: Clinical Risk Score + CAC + CFR|
|Fit Statistic||HR||p Value||Fit Statistic||HR||p Value||Fit Statistic||HR||p Value||Fit Statistic||HR||p Value|
|Global chi-square test||19.0||ref||24.4||0.02||44.5||<0.0001||46.7|
|c-index||0.632 (0.550−0.714)||ref||0.644 (0.561−0.728)||0.58||0.719 (0.647−0.791)||0.004||0.719 (0.651−0.788)|
|Duke clinical risk score (per 10%)||1.06 (1.03−1.10)||<0.0001||1.05 (1.02−1.08)||0.003||1.06 (1.03−1.10)||0.0002||1.05 (1.02−1.09)||0.004|
|CAC (per 2-fold increase)||1.09 (1.01−1.17)||0.02||1.06 (0.98−1.13)||0.14|
|CFR (per 10% increase)||0.82 (0.76−0.89)||<0.0001||0.83 (0.76−0.89)||<0.0001|
A log transformation of the Duke clinical risk score, CFR and CAC + 1 were used for the analyses to adjust for the rightward skew of the data and to reduce heteroscedasticity. Global chi-square test indicated likelihood ratio chi-square statistic for the entire model. p Values for model fit statistics (i.e., global chi-square test, AIC and c-index) are for comparisons with model 1, unless specified. C-indices are calculated for 3-year event date.
AIC = Akaike information criterion; other abbreviations as in Table 3.
↵⁎ The components to calculate Duke clinical risk score consist of age, sex, typical angina, atypical angina, history of myocardial infarction, ECG Q-wave, ECG ST-T wave changes, smoking, dyslipidemia, diabetes, age by sex, history of myocardial infarction by electrocardiogram Q-wave, age by sex, age by dyslipidemia, and sex by smoking (interaction) (11).