Author + information
- Received January 24, 2013
- Revision received March 31, 2013
- Accepted April 23, 2013
- Published online September 17, 2013.
- Elif Seda Selamet Tierney, MD∗,†∗ (, )
- Dana Gal, BA∗,
- Kimberly Gauvreau, ScD∗,
- Annette L. Baker, MSN, PNP∗,
- Shari Trevey, RDCS∗,
- Stephen R. O'Neill, JD, RDCS∗,
- Michael R. Jaff, DO‡,
- Sarah de Ferranti, MD, MPH∗,
- David R. Fulton, MD∗,
- Steven D. Colan, MD∗ and
- Jane W. Newburger, MD, MPH∗
- ∗Department of Cardiology, Boston Children's Hospital, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts
- †Division of Pediatric Cardiology, Department of Pediatrics, Stanford University, Stanford, California
- ‡Department of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts
- ↵∗Reprint requests and correspondence:
Dr. Elif Seda Selamet Tierney, Pediatric Heart Center, Stanford University, 750 Welch Road, Suite 350, Mail Code: 5731, Palo Alto, California 94304.
Objectives The objective of our study was to compare the indices of vascular health in Kawasaki disease (KD) patients to those of control subjects.
Background The literature on peripheral vascular health after KD is conflicting.
Methods Subjects were patients 11 to 29 years of age with the onset of KD >12 months before the study visit (n = 203) and healthy control subjects (n = 50). We measured endothelial function (using the Endothelial Pulse Amplitude Testing index), intima-media thickness (IMT) of the right common carotid artery (RCCA) and the left common carotid artery (LCCA), and fasting lipid profile and C-reactive protein (CRP). KD patients were classified according to their worst-ever coronary artery (CA) status: group I, always normal CAs (n = 136, 67%); group II, CA z-scores ≥2 but <3 (n = 20, 10%); group III, CA aneurysm z-scores ≥3 but <8 mm (n = 40, 20%); and group IV, giant CA aneurysm, defined as ≥8 mm (n = 7, 3%).
Results At a median of 11.6 years (range, 1.2 to 26 years) after KD onset, compared with controls, KD patients had a higher peak velocity in the LCCA (p = 0.04) and higher pulsatility index of both the RCCA and LCCA (p = 0.006 and p = 0.05, respectively). However, there were no differences in the Endo-PAT index or carotid IMT or stiffness. The mean IMT of the LCCA tended to differ across the KD subgroups and control group (p = 0.05), with a higher mean in group IV. Otherwise the KD subgroups and control group had similar vascular health indexes.
Conclusions In contrast to some earlier reports, our study of North American children and young adults demonstrated that KD patients whose maximum CA dimensions were either always normal or mildly ectatic have normal vascular health indexes, providing reassurance regarding peripheral vascular health in this population.
Supported by the American Heart Association, National Scientist Development Award, and the Farb and McCance Family Funds. The authors have reported that they have no relationships relevant to the contents of this paper to disclose.
- Received January 24, 2013.
- Revision received March 31, 2013.
- Accepted April 23, 2013.
- 2013 American College of Cardiology Foundation