Author + information
- Received March 27, 2013
- Revision received May 8, 2013
- Accepted May 10, 2013
- Published online October 1, 2013.
- Chia-Ying Liu, PhD∗,†,
- Yuan-Chang Liu, MD∗,‡,§,
- Colin Wu, PhD‖,
- Anderson Armstrong, MD§,
- Gustavo J. Volpe, MD§,
- Rob J. van der Geest, PhD¶,
- Yongmei Liu, MD, PhD#,
- William G. Hundley, MD∗∗,
- Antoinette S. Gomes, MD††,
- Songtao Liu, MD†,
- Marcelo Nacif, MD, PhD∗,†,
- David A. Bluemke, MD, PhD∗,†,§ and
- João A.C. Lima, MD∗,§∗ ()
- ∗Department of Radiology, Johns Hopkins University, Baltimore, Maryland
- †Radiology and Imaging Sciences, National Institutes of Health, Bethesda, Maryland
- ‡Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Linkou, College of Medicine, Chang Gung University, Taipei, Taiwan
- §Cardiology Division, Department of Medicine, Johns Hopkins Hospital, Baltimore, Maryland
- ‖Office of Biostatistics, National Heart, Lung, and Blood Institute, Bethesda, Maryland
- ¶Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands
- #Department of Epidemiology and Prevention, Wake Forest University, Winston-Salem, North Carolina
- ∗∗Department of Internal Medicine, Wake Forest University, Winston-Salem, North Carolina
- ††Department of Medicine, University of California, Los Angeles, Los Angeles, California
- ↵∗Reprint requests and correspondence:
Dr. João A. C. Lima, Division of Cardiology, The Johns Hopkins Hospital, Blalock 524D, 600 North Wolfe Street, Baltimore, Maryland 21287.
Objectives This study sought to determine the relationship of cardiovascular magnetic resonance (CMR) measures of tissue composition to age in the Multi-Ethnic Study of Atherosclerosis (MESA).
Background Animal and human studies have demonstrated increased collagen deposition in senescent hearts. New CMR indices of tissue composition by using T1 mapping are sensitive to the presence of myocardial fibrosis.
Methods A total of 1,231 study participants (51% women; age range 54 to 93 years) of the MESA cohort were evaluated with T1 mapping by using 1.5-T CMR scanners. None of the participants had focal scar on delayed enhancement CMR. Single-slice T1 mapping was performed at the midventricular level before and at 12- and 25-min delay after administration of gadolinium contrast by using a modified Look-Locker inversion recovery sequence. The partition coefficient was determined by the slope of the linear relationship of (1/T1myo vs. 1/T1blood). The extracellular volume fraction (ECV) was derived accounting for the hematocrit level. Multivariable regression analyses were performed, adjusting for traditional risk factors and left ventricular structure.
Results Women had significantly greater partition coefficient, ECV, and precontrast T1 than men, as well as lower post-contrast T1 values (all p < 0.05). In general, linear regression analyses demonstrated that greater partition coefficient, pre-contrast T1 values, and ECV were associated with older age in men (multivariate regression coefficients = 0.01; 5.9 ms; and 1.04% per 10 years' change; all p < 0.05). ECV was also significantly associated with age in women after multivariable adjustments.
Conclusions CMR parameters that have been associated with myocardial fibrosis were related to older age in the MESA study. Women had higher ECV than men but less ECV change over time.
This research was supported by contracts N01-HC-95159 through N01-HC-95168 from the National Heart, Lung, and Blood Institute. Dr. van der Geest has served as a consultant for Medis Medical Imaging Systems. Dr. Lima has a relationship with Bayer HealthCare. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose. Deborah Kwon, MD, served as Guest Editor for this paper.
- Received March 27, 2013.
- Revision received May 8, 2013.
- Accepted May 10, 2013.
- 2013 American College of Cardiology Foundation