|Outcome||Event Rate by Fertility Therapy (per 100,000 Person-Years)||Hazard Ratio (95% CI)|
|Major cardiovascular events||(n = 1,179,774)||(n = 6,979)|
|Death or cardiovascular event||117.0||102.6||0.96 (0.72–1.29)||0.55 (0.41–0.74)|
|Death||53.8||41.9||0.94 (0.59–1.50)||0.50 (0.31–0.80)|
|Cardiac ischemia||16.7||14.0||1.23 (0.55–2.74)||0.56 (0.25–1.25)|
|Heart failure||14.6||18.6||1.13 (0.56–2.26)||0.60 (0.30–1.22)|
|Venothromboembolic events||28.0||16.3||0.54 (0.26–1.13)||0.45 (0.21–0.94)|
|Cerebrovascular events||8.5||16.3||2.14 (1.02–4.50)||1.14 (0.54–2.44)|
|Emergent cardiovascular risk factors†||(n = 1,108,322)||(n = 6,394)||‡|
|Any hypertension, diabetes, or hyperlipidemia||3,831||5,907||1.53 (1.46–1.60)||0.86 (0.82–0.90)|
|Hypertension||1,985||2,945||1.52 (1.43–1.61)||0.88 (0.83–0.94)|
|Diabetes mellitus||1,046||1,816||1.68 (1.56–1.81)||0.93 (0.86–1.00)|
|Hyperlipidemia||1,393||2,094||1.63 (1.52–1.75)||0.85 (0.79–0.91)|
Hazard ratios represent the risk among women with fertility compared with women without fertility therapy (reference).
CI = confidence interval.
↵∗ Risk adjusted for age, calendar year, geographic residence, neighborhood income, prior physician visits, antenatal visits to an obstetrician, prior medical history (including hypertension, hyperlipidemia, diabetes mellitus [including gestational diabetes], neoplasm, alcoholism, female infertility, endometriosis, polycystic ovarian syndrome, sexually transmitted infections, pelvic inflammatory disease, other genital tract disorders, prior ovarian hyperstimulation syndrome, prior vaginal delivery, prior Cesarean delivery, prior multiple gestation, and prior abnormal pregnancy), length of stay and obstetrical characteristics for the index delivery (including number of gestations, number of complicated gestations, Cesarean delivery, operative delivery, assisted labor procedures, disproportion, abnormality of pelvic organs, suspected fetal problems, amniotic fluid and uterine cavity abnormalities, and other serious obstetrical complications).
↵† Analyses restricted to patients without history of prior cardiovascular disease, hypertension, diabetes (including gestational diabetes), or hyperlipidemia at baseline.
↵‡ Risk adjusted for all variables listed above except hypertension, diabetes (including gestational diabetes), and hyperlipidemia.