|Outcome||Events Rate by Fertility Therapy (per 100,000 Person-Years)||Hazard Ratio (95% CI)|
(n = 1,179,774)
(n = 6,979)
|Breast||33.1||39.6||1.42 (0.88–2.28)||0.74 (0.45–1.19)|
|Ovarian||5.6||9.3||2.04 (0.76–5.46)||1.12 (0.41–3.05)|
|Melanoma||0.9||2.3||2.85 (0.40–20.5)||1.80 (0.24–13.7)|
|Pneumonia||49.5||49.0||1.00 (0.65–1.54)||0.73 (0.47–1.13)|
|Nephrolithiasis||40.7||32.6||0.75 (0.45–1.27)||0.71 (0.42–1.21)|
|Alcoholism||164.7||84.2||0.53 (0.38–0.73)||0.48 (0.35–0.67)|
|Sexually transmitted infections||538.2||351.0||0.63 (0.54–0.74)||0.64 (0.55–0.76)|
|Motor vehicle collisions||37.1||16.3||0.44 (0.21–0.92)||0.51 (0.24–1.07)|
|Depression||76.0||26.0||0.32 (0.18–0.58)||0.33 (0.18–0.59)|
|Self-harm||48.1||4.7||0.09 (0.02–0.35)||0.15 (0.04–0.62)|
Values are %. Hazard ratios represent the risk among women with fertility compared with women without fertility therapy (reference).
CI = confidence interval.
↵∗ Risk adjusted for age, calendar year, geographic residence, neighborhood income, prior physician visits, antenatal visits to an obstetrician, prior medical history (including hypertension, hyperlipidemia, diabetes mellitus [including gestational diabetes], neoplasm, alcoholism, female infertility, endometriosis, polycystic ovarian syndrome, sexually transmitted infections, pelvic inflammatory disease, other genital tract disorders, prior ovarian hyperstimulation syndrome, prior vaginal delivery, prior Cesarean delivery, prior multiple gestation, and prior abnormal pregnancy), length of stay and obstetrical characteristics for the index delivery (including number of gestations, number of complicated gestations, Cesarean delivery, operative delivery, assisted labor procedures, disproportion, abnormality of pelvic organs, suspected fetal problems, amniotic fluid and uterine cavity abnormalities, and other serious obstetrical complications).