Author + information
- Abdulkadir Yıldız1,
- Abdullah Tuncez2,
- Enis Grbovic3,
- Nihat Polat1,
- Murat Yuksel1,
- Mesut Aydin1,
- Mustafa Oylumlu1,
- Halit Acet1,
- Mehmet Zihni Bilik1,
- Mehmet Ata Akil1,
- Hasan Kaya1,
- Faruk Ertas1 and
- Muhammed Cebeci3
The neutrophil/lymphocyte ratio (NLR) is an inexpensive, readily available and reliable inflammatory marker which has a predictor value in different cardiovascular disorders. Functional capacity is one of the most important prognostic factor in patients with heart failure. In this study, we aimed to investigate the relationship between NLR and functional capacity (FC) in patients with idiopathic dilated cardiomyopathy (IDC).
Treadmill test according to modified-Bruce protocol was performed in 37 patients with IDC (mean age 46.5 ± 11 years,19% female) to assess their functional capacity. Baseline clinical and echocardiographic variables were obtained. Hematologic parameters were measured using an automatic blood counter.
The patients were divided into low (<5 METs, n=18) and high (>5 METs, n=19) FC groups according to their functional status. There was no significant difference between 2 groups regarding age, sex, echocardiographic parameters, hemoglobin, red cell distribution width (RDW), white blood cell and platelet counts. However, the NLR was significantly higher in low FC group compared to high FC group (3.6 ± 2.4 vs 2.2 ± 0.7, p=0.007; respectively). There were significant correlations between the NLR and METs, RDW, left ventricular diastolic diameter (r:-0.405, p=0.013, r:0.613, p<0.001 and r:0.600, p=0.001; respectively). Diastolic dysfunction was present in all of the patients with low functional capacity.
We detected a significant association between the NLR and low functional capacity both of which has predictive and prognostic value in patients with heart failure. Functional capacity may be determined by diastolic function rather than left ventricular ejection fraction.
|Age, years||46 ± 14||47 ± 11||0.761|
|Male sex, n (%)||16 (88.9)||14 (73.7)||0.238|
|Hypertension, n (%)||4 (22.2)||6 (31)||0.714|
|Diabetes, n (%)||4 (22.2)||3 (15.8)||0.693|
|Body mass index, kg/m2||24.9 ± 3.2||27.3 ± 5.0||0.214|
|Hemoglobin, g/L||13.8 ± 1.8||14.4 ± 1.1||0.307|
|Red cell Distribution width||15.5 ± 1.8||14.6 ± 0.6||0.061|
|Platelet count, /mm3||256 ± 106||241 ± 55||0.625|
|White blood cell count, x103/μL||8.3 ± 1.6||7.9 ± 1.8||0.605|
|Neutrophil to lymphocyte ratio||3.6 ± 2.5||2.2 ± 0.7||0.007|
|QRS duration, msn||104 ± 24||88 ± 21||0.062|
|Left ventricular diastolic diameter, mm||68 ± 8||65 ± 5||0.645|
|Left ventricular ejection fraction, %||26 ± 7||28 ± 7||0.426|
|Diastolic dysfunction, n (%)||18 (100)||13 (68.4)||0.020|