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Novel studies which investigated extraskeletal effects of vitamin D showed that vitamin D plays important role in whole body health, beyond bone health. Vitamin D receptors are present in various cell types including osteoblasts, cardiomyocytes, myocytes, endothelium, immune cells and neurons. Vitamin D deficiency is defined as 25-hydroxy D3 values ≤20 ng/ml and its prevalence varies from 27% to 55% in different series. Decline in systolic and diastolic functions of the heart has been reported in patients with vitamin D deficiency.In this study, we aimed to investigate short-term effects of vitamin D treatment on systolic and diastolic functions of the heart in patients with vitamin D deficiency.
Fifty patients (3 male/ 47 female, mean age 46±12 years) diagnosed as having vitamin D deficiency and osteoporosis were included in this study. All patients underwent detailed transthoracic echocardiography for evaluation of left ventricular systolic and diastolic functions of the heart.Oral Vitamin D was administered to all study paitents for 8 days (a total of 300.000 IU). Transthoracic echocardiography was repeated for all patients at 30th days.
After one month treatment with oral Vitamin D, serum 25-hydroxy D3 value increased from 11±4 ng/ml to 21±5 ng/ml, p<0.001). After initiation of supplementary vitamin D treatment LVEF (62,6±5% to 63.8 ± 4, p=0.025) indicating LV systolic function improved significantly. Also mitral E/A ratio, a measure of diastolic function, improved significantly after treatment with vitamin D treatment (1.16±0.3 to 1.2±0.3, p=0.028). However, IVCT (95.2±15 to 96±13, p=0.54) and EDEC (197±28 to 197±22, p=0.95) were similar to baseline values. Change in serum level of vitamin D (▵Vit D) was correlated with change in LVEF (▵EF, r=0.39 and p=0.005) and change in mitral E/A ratio (▵E/A, r=0.340 and p=0.016). Linear regression analysis revealed that change in serum 25-hydroxy D3 level (▵Vit D) was significantly associated with change in LVEF (▵EF) (coefficient-β=0.36, p=0.013).
Results of this study show that supplementary vitamin D treatment leads to improvement in LV systolic and diastolic function in patients with vitamin D deficiency, even at short term follow-up. Our results also show that change in Vitamin D level is significantly associated with improvement in LVEF.