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Rheumatic valve disease is an important public health problem in developing countries. We sought to evaluate the possible role of blood antigens as risk factors for rheumatic valve disease.
Two hundred fifty four patients with severe rheumatic mitral and/or aortic valve disease in whom referred to surgery were enrolled to the study. Blood groups of the patients were determined using standard haemagglutination tests. Control group was consisted of 2668 healthy volunteers who donated blood to the Turkish Red Crescent in Gaziantep region.
There were 216 patients with aortic valve involvement and 249 patients with mitral valve involvement. 175 patients had mitral stenosis, 96 patients had severe mitral regurgitation and 61 patients had severe aortic regurgitation. Blood groups of the patients were as follows: Group A=42.9%, Group B=19.2%, Group AB=8.6%, Group O=29.1%. Blood groups of the control group were Group A= %40.8, Group B=%16.4, Group AB=%7.6, Group O=%35.1. There was not any significant difference between blood groups of patients and controls (p=0.141).
There is no association between the rheumatic valve disease and healthy individuals living in Southeastern Anatolian endemic region in terms of their profile of blood group antigens. Blood group is not seem to be a risk factor for rheumatic valve involvement or the severity of the disease.