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Platelet activity plays an important role in the pathogenesis of atherosclerotic vascular disease. Increase in platelet volume is correlated with the activity of the platelet. It has been reported that mean platelet volume has increased before the acute myocardial infarction. In our study, the difference between the mean platelet volume were investigated in patients presenting with chest pain and those with a diagnosis of acute coronary syndrome or not.
250 patients (63.2% male, mean age 63.30±13.86) with the diagnosis of acute coronary syndrome and treated in coronary intensive care unit were evaluated. Patients were divided into three subgroups such as ST elevation (STEMI) and non-ST elevation myocardial infarction (NSTEMI) and unstable angina pectoris (USAP). Fifty patients (46% male, mean age 56.26±15.18) who admitted to the emergency department with chest pain but were not diagnosed with acute coronary syndrome, were included in the study as a control group. Clinical evaluation was performed and cardiac risk factors were recorded. In patients with acute myocardial infarction blood samples for platelet count and mean platelet volume were taken into tubes containing EDTA during hospital admissions and prior to the standard treatment regimen but in the control group blood samples were taken into tubes containing EDTA in the emergency clinic. The normal mean platelet volume values are between 7.8 to 11 fL values and values above 11.1 fL were accepted as high.
Average MPV values in the patient group was statistically significantly higher than the control group (10.43±0.80 and 10.11±0.95 fl, p=0.029). In the 26.4% of patient group and 8% of control group, MPV values were above the normal (≥ 11,1) (p=0.005). There was no significant difference between MPV values of NSTEMI, STEMI, and USAP groups (p=0.316). The mean platelet count was lower in the patient group but no statistically significant difference was observed compared to the control group (230×103/mm3 and 246×103/mm3, p=0.127). Cardiac risk factors such as diabetes mellitus was significantly correlated with the mean MPV values (10.34±0.91 in those without diabetes, 10.66±1.03 in those with diabetes, p=0.019).
The mean platelet volume was significantly higher in the acute phase of coronary heart disease. Although not statistically significant, decrease in platelet counts observed during the acute phase. The presence of diabetes, independent of other factors, influence the size of the platelet.
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SD: Standard Deviation