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Right ventricular (RV) dysfunction may develop in the course of chronic obstructive pulmonary disease (COPD) and it is important predictor of morbidity and mortality. The polymorphism of the gene of multidrug resistance-1 (MDR-1) responded to drug resistance have been associated with some worse clinical findings in patients with COPD. In this study, we aimed to investigate the relationship between MDR-1 C3435T gene polymorphism and RV dysfunction in COPD patients.
Forty one consecutive patients diagnosed priory with COPD and hospitalized for acute exacerbation were enrolled. The polymorphism analysis was performed by Strip Assay technique. Right ventricular parameters were evaluated, and RV dysfunction was identified via transthoracic echocardiography. Patients were categorized into three groups according to gene polymorphism; MDR-1 CC (Wild Type, n=9), MDR-1 CT (Heterozygote mutant, n=21) and MDR-1 TT (Homozygote mutant, n=11).
The study included 14 male and 27 female, mean age 65±11 years. Mean systolic pulmonary artery pressure was 31.4±8 mmHg in wild type group, 42.2±12 mmHg in heterozygote mutant group and 46.5±14 mmHg in homozygote mutant group (p=0.027) (Figure 1). Furthermore, presence of RV dilatation was significantly different among three groups (33%, 71%, and 100%, respectively, p=0.005). In multiple logistic regression analysis, MDR-1 C3435T gene polymorphism (OR=9.000, p = 0.019) was independent predictor of RV dysfunction after adjustment of potential confounders.
The findings of this study demonstrate that MDR-1 C3435T gene polymorphism is associated with RV dysfunction in patients with COPD.