Author + information
- Serpil Eroğlu,
- Elif Sade,
- Emre Özçalık,
- Gökhan Özyıldız,
- Uğur Abbas Bal,
- Ersin Doğanözü and
- Haldun Müderrisoğlu
There is cumulating evidence that show an association with vitamin D deficiency and cardiovascular disease. In this study we aimed to investigate the relationship between vitamin D levels and the presence and severity of coronary artery disease.
In all, 79 patients (31 female and 48 male, mean ages 54.7±9.1 years) who had coronary angiography were enrolled. 25 (OH) D3 levels were measured in all patients in winter season. Carotid intima media thickness was evaluated. Gensini scores were calculated. We compared vitamin D levels with the presence and severity of coronary artery disease and carotid intima media thickness.
According to coronary angiography 46 patients had coronary artery disease and 33 patients had normal coronary arteries. Mean Vitamin D level was 22.4±12.7μg/L. Vitamin D levels were reduced in patients with coronary artery disease compared with in patients with normal coronary arteries (22.4±12.7 vs. 26.5±15.7 P=0.008) (Figure 1). When the patients were separated in to 3 groups the according to the severity of coronary artery disease such as normal coronary arteries, single vessel disease and multivessel disease; vitamin D levels were found to be lowest in multivessels disease group (Figure 2). Vitamin D levels were inversely correlated with Gensini scores (r=-0.339 P=0.003) and carotid intima media thickness (r=-0.312 P=0.031).
Vitamin D levels are associated with the presence and severity of coronary artery. Vitamin D deficiency may impact coronary artery disease and merits further investigation for the prevention of coronary artery disease.