Author + information
- Osman Kuloğlu,
- Mustafa Gür,
- Taner Şeker,
- Gülhan Yüksel Kalkan,
- Durmuş Yıldıray Şahin,
- Nermin Yıldız Koyunsever,
- Hazar Harbalıoğlu,
- Caner Türkoğlu,
- Selahattin Akyol,
- Zafer Elbasan,
- Armağan Acele and
- Murat Çaylı
Vitamin D may modulate vascular inflammation, vascular smooth muscle cell proliferation, the renin-angiotensin system, and cardiomyocyte proliferation, myocardial fibrosis and proliferation. These mechanisms may play a role on arterial stiffness and left ventricle hypertrophy in hypertensive patients. We aimed to evaluate the association between serum vitamin D with arterial stiffness and left ventricle hypertrophy (LVH) in patients with hypertension.
We studied 133 patients with newly diagnosed hypertension (mean age; 62.9±10.6 years). Pulse wave velocity (PWV), which reflects arterial stiffness, was calculated using the single-point method via the Mobil-O-Graph® ARCsolver algorithm. Left ventricle mass index (LVMI) was determined according to Deverux formula. The patients were divided into two groups according to serum vitamin D level; vitamin Dlow group <20 ng/ml and vitamin Dhigh group ≥20 ng/ml.
The highest PWV, high sensitive C reactive protein (hs-CRP) and LVMI values were observed in vitamin Dlow group compared with vitamin Dhigh group (Table). Multiple linear regression analysis showed that vitamin D level was independently associated with LVMI (β=-0.235, p=0.002) and PWV (β=-0.432, p<0.001). Adjustment for age, sex, parathyroid hormone level, body surface area and mean blood pressure did not modify these associations. Vitamin D level was also independently associated with hs-CRP (β=-0.143, p=0.047). But adjustment for parathyroid hormone level or body surface area and mean blood pressure attenuate this association.
Serum 25-hyroxyvitamin D is independently related with arterial stiffness, LVH and inflammation. Vitamin D may play a role on pathogenesis of arterial stiffness and LVH in patient with newly diagnosed hypertension.
|Variables||Vit Dhigh Group||Vit Dlow Group||P value|
|Hs-CRP (mg/dl)||0.30 (0.20-0.72)||0.40 (0.20-1.10)||0.021|
|Vitamin D (ng/mL)||24.1±3.8||9.5±4.0||<0.001|
Hs-CRP; high sensitive C reactive protein, LVMI; left ventricular mass index, PWV; pulse wave velocity