Author + information
- Osman Kuloğlu1,
- Mustafa Gür1,
- Taner Şeker1,
- Gülhan Yüksel Kalkan1,
- Sinan Kırım2,
- Durmuş Yıldıray Şahin1,
- Hazar Harbalıoğlu1,
- Caner Türkoğlu1,
- Armağan Acele1,
- Zafer Elbasan1,
- Betül Özaltun1 and
- Murat Çaylı1
Epidemiological studies suggested that there were an inverse association between vitamin D status with risk and presence of type 2 diabetes mellitus (DM). Although vitamin D is effective on fragmentation of elastic fibers in the aortic media, relationship between vitamin D status and elastic property of aorta (aortic distensibility) has not been investigated in diabetic patients. We aimed to evaluate the association between serum vitamin D status and aortic distensibility in patients with DM.
We studied 136 patients with newly diagnosed DM (mean age; 62.9±10.6 years). The patients were divided into two groups according to the serum 25-hyroxyvitamin D level (Vitamin Ddeficiency group <20 ng/ml (n=80) and vitamin Dsufficient group ≥20 ng/ml (n=56)). Serum 25-hyroxyvitamin D was measured using a direct competitive chemiluminescent immunoassay. Aortic distensibility was calculated from the echocardiographically derived ascending aorta diameters and hemodynamic pressure measurements. Left ventricle mass index (LVMI) was determined according to Deverux formula.
The lowest aortic distensibility values and highest hs-CRP and LVMI values were observed in vitamin Ddeficiency group compared with vitamin Dsufficient group (p<0.05 for all) (Table). Multiple linear regression analysis showed that vitamin D level was independently associated with LVMI (β=-0.259, p=0.001), aortic distensibility (β=0.369, p<0.001), hs-CRP (β=-0.220, p=0.002) and body mass index (β=-0.167, p=0.015) in patients with DM.
In diabetic patients, serum 25-hyroxyvitamin D level was independently associated with aortic distensibility. Vitamin D may play a role on pathogenesis of impaired elastic properties of aorta in type 2 DM.
|Variables||Vitamin Ddeficency Group (n=80)||Vitamin Dsufficient Group (n=56)||P value|
|Aortic Distensibility (cm2 dyn-1 x10-6)||2.67±1.49||3.41±1.44||0.005|
Hs-CRP; high sensitive C reactive protein, LVMI; left ventricular mass index