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Atherosclerosis and osteoporosis have been considered as seperate disease. And the correlation between atherosclerosis and osteoporosis has been investigated recently in a numerous clinical studies. Since the growing scientific evidence have shown a lot of underlying parallel pathophysiological mechanisms and due to similarity in risk factors and to treatment of one disease that affect the other, idea has come out that this me be a single disorder. Many common risk factors for osteoporosis and atherosclerosis can coexist together in postmenopausal women, glucocorticoid induced osteoporosis and elderly men. As both chronic degenerative diseases, the incidence of CVD and osteoporosis increase for both gender and with age. The objective of this paper was to study the eventual association of joint cardiovascular sisk risk factors and osteoprosis.
Total of 104 patients suffering from definite glucocorticoid induced osteoporosis (GIO) and postmenopausal osteoporosis (PO) were examined for CV risk factors, concomitant diseases and the use of glucocorticoids. Cardiovascular risk factors were analysed in all osteoporotic patients and distributed in a two separate groups. The retrospective clinical study was done. There were 93 females (89,6%) and 14 males (10,4%). The average age in total was 63,16 years In the female group the average age was 65,35 years (range 39-90y), while in the male group it was 64,17 years (range 46 – 78y). The most frequent cause of OP was glucocorticosteroid induced osteoporosis (GIO) observed in 71 (68,27%) of patients and 33 (31,73%) patients with postmenopausal osteoporosis. The following cardiovascular risk factors were determined in this study: Smoking, Arterial Hypertension, Cholesterol, Tryglycerides, Glucocorticosteroids, diabetes, and other concomitant diseases and BMD.
The results from this study have shown the significant influence of cardiovascular risk factors and concomitant disorders on osteoporosis. Majority of patients were females and within the age of approximately 65 years old. The major disorder was rheumatoid arthritis in 52 patients and thyreoid disease was also very common. The lipid profile was increased in 61 patients, smoking in 42 individuals and arterial hypertension in 46 patients. The glucocorticosteroid was used by more than half of the study population in 67 patients or 65,7%.
The results obtained from our study have shown that there is association between cardiovascular risk factors and osteoporosis in lipid abnormalities, smoking, arterial hypertension, gender, age, underlying disorders and use of corticosteroids. This study and many other studies from other authors have brought us to conclusion that atherosclerosis and osteoporosis may be the one single disease. More epidemiological and investigative studies are needed to prove this hypothesis.