Author + information
- Snezhanka Tisheva1,
- Edward Mekenyan1,
- Nadia Stancheva1,
- Milena Atanasova2 and
- Konstantin Gospodinov1
Atherosclerosis is a chronic, progressive disease that affects the inner layer of the large and medium arteries of the body. Number of risk factors, components of metabolic syndrome, contribute for its earlier manifestation and progression. The primary mechanism for avoiding the complications of the atherosclerotic process is an early detection of the vascular aging and prevention. So far the risk stratification is performed by the SCORE RISK CHART. Vascular aging is associated with accelerated turnover of the febrile protein elastin wich is the main component in the structure of the vessel wall. A constellation of markers are required for proper risk stratification and early assessment of the morphological vascular changes.
To determine the correlation between the levels of the immunological markers against elastin, and the stratified risk by the SCORE chart.
A study is conducted on 104 subjects. All subjects were stratified according to the SCORE risk chart into three groups: high, moderate and low risk. To determine the least significant differences (LSD) between the groups we used the method of Fisher.
When comparing the mean levels of AEAb IgG in the three groups we determined a statistically significant difference at 95% confidence interval between the group with low and high risk (LSD=0,372, p<0.05), between the group with low and intermediate risk (LSD=0,147, p<0.05) between the group with intermediate and high risk (LSD=0,225, p<0.05). p=0.000 No such correlation could be determined between the levels of AEAb IgM in the three risk groups.
AEAb IgM are an acute phase antibodies associated with the initiation of the process of elastin turnover. Vascular aging is a long process, wich is accompanied by high levels of AEAb IgG. The predictive value of the SCORE chart and AEAb IgG is comparable - the higher the turnover of febrile protein, the higher the cardiovascular risk of the patient as assessed by the SCORE risk chart. Therefore, the high vascular risk is preceded by a more intensive process of elastin turnover.