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Increased serum gamma-glutamyl transpherase levels (GGT) has been shown to directly promote oxidative stress. In previous studies has been shown the relationship between the dilatation of the ascending aorta with oxidative stress. This study was designed to examine the relationship between serum GGT concentrations with dilatation of the ascending aorta.
83 patients with ascending aorta dilatation and 82 healthy person matched of age and sex were included in the study. The patients were evaluated by a complete transthoracic echocardiographic examination including measurement of the aortic dimensions. 4 cm and above ascending aorta dilatation was accepted. Serum GGT concentration were measured in all patients.
66 % of 83 patients with ascending aorta dilatation were male and average age were 56±12.1. In the control group 63% of 82 healthy person were male and average age were 55±11.3. In the group of ascending aorta dilatation; tension, left ventricular mass index, left atrial volume index, serum GGT, serum üric acid, hs- CRP were found to be significantly higher than control group. According to multiple logistic regression; hypertension history (OR:1.22, 95%CI 1.12-1.32, p<0.05), serum GGT (OR:1.09, 95%CI 1.04-1.14, p<0.05) for ascending aorta dilatation were found to be independent variables.
In conclusion, we found that serum GGT concentration was significantly associated with aortic dilatation. The higher serum GGT concentration may be responsible for the elevated serum antioxidant capacity that was observed among patients with ascending aorta dilatation. Large epidemiological studies are required to correlate the findings from this study with clinical outcome.