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To evaluate the relationship between the endothelial dysfunction assessed by flow mediated dilation (FMD) in the brachial artery and serum total antioxidant status (TAS) in SLE patients.
Thirty-four patients with SLE and thirty-nine healthy volunteers without any cardiovascular disease and atherosclerotic risk factors were included in this study. Doppler ultrasound system was used to measure FMD from the brachial artery in the antecubital fossa to assess endothelial function. Serum TAS was measured with TAS kit. High-sensitivity C-reactive protein (hs-CRP), a marker of inflammation, was also determined.
The mean TAS value was significantly lower in patients with SLE than in controls (1.60±0.11 versus 1.73±0.15; p<0.0001). hs-CRP levels were significantly higher in patients with SLE than in controls (8.2±6.0 vs 2.9±4.0; p<0.0001). There was no difference between groups regarding baseline and hyperemic diameters. However, FMD percent was found to be significantly lower in SLE patients than in controls. FMD significantly positively correlated with TAS (r=0.448, p=0.001) and significantly inversely correlated with serum hs-CRP levels (r=-0.314, p=0.001). In regression analysis, only TAS was independently correlated with FMD (b=0.575, p=0.002).
SLE patients without cardiovascular risk factors have endothelial dysfunction and this can be releated with underlying inflammation and impairment of TAS.