Author + information
- Burak Hünük1,
- Özgür Çağaç2,
- Okan Erdoğan2,
- Alper Kepez2,
- Bülent Mutlu2,
- Muzaffer Değertekin3 and
- Çetin Erol4
Serum uric acid (SUA) has antioxidant properties and has recently been associated with many cardiovascular (CV) risk factors. The aim of the present study was to determine the relationship between SUA and prevalence of AF in a population based data.
Surface ECGs were obtained from the HAPPY (Heart Failure Prevalence and Predictors in Turkey) study including randomly selected 4650 subjects ≥35 years with laboratory and clinical data from Turkey. After exclusion of subjects with missing data; 3973 subjects ([mean±SD]age, 52±11, [range]35-100 years) were enrolled in the study (female n [overall%]:2251 [56,7%]). All ECGs were interpreted manually by two experienced cardiologists for the presence of AF.
The prevalence of AF was 1,6% in Turkish population with a significant incline in the older age groups (35-54, 55-64, ≥65 [years]; 0,6%, 1,9%, 4,2% respectively, p<0,001) and more prevalent in men (2,1% vs 1,2% p<0,001). Mean SUA was (mean±SEM) 4,6±0,02 mg/dl in the overall population being significantly higher in men (5,2±0,03 vs 4,1±0,02 p<0,001). SUA was significantly higher in subjects with AF (5,4±0,17 vs 4,6±0,02 p<0,001). In multivariate logistic regression analyses, SUA level was an independent predictor of AF in general Turkish population after adjusting for age, gender, hypertension, coronary artery disease, diabetes, glomerular filtration rate and body mass index (OR: 1,30 CI: 1,10-1,52 p=0,001) (Table-1).
SUA was significantly associated with crude AF prevalence in Turkish population suggesting a link between SUA and AF as well as various traditional CV risk factors affecting the pathogenesis of AF.
CAD: Coronary artery disease, GFR: Glomerular filtration rate, BMI: Body mass index, OR: Odds ratio, CI: Confidence interval, SUA: Serum uric acid