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Background and Aim
Dilated cardiomyopathy (DCM) is a progressive disease of heart muscle characterized by contractile dysfunction and ventricular dilatation with normal left ventricular wall thickness. There are many causes of cardiomyopathy including hereditary diseases, infections and toxins whereas ischemic cardiomyopathy is the most common cause of cardiomyopathies in North America and Europe. We aimed to investigate aortic strain (AS), aortic distensibility (AD) and aortic propagation velocity (APV) in DCM patients with either critical or non-critical coronary artery disease.
The patients who underwent coronary angiography with complaint of angina at our institution were included in the study. 50 DCM patients with critical coronary artery stenosis of > 50% in at least one epicardial coronary artery, 56 DCM patients with non critical coronary artery stenosis of < 50%, 53 patients with normal coronary arteries were included in the study. Age, gender, weight, height, and biochemical parameters were noted and echocardiographic AS, AD, APV measurements were made. Groups were compared with either one way analysis of variance (ANOVA) or Kruskal Wallis tests with regard to continuous variables and Pearson chi-square test with regard to categorical variables. Pearson correlation was used to identify parameters correlated with APV, AS, AD whereas linear regression analysis was used to assess independent predictors of these parameters.
There were significant differences among four groups with regard to AS (ANOVA p<0,001), AD (ANOVA p<0,001), APV (ANOVA p<0,001) (Fig. 1, 2, 3). APV was significantly correlated with both AS (r=0,644, p<0,001) and AD (r=0,601, p<0,001).
APV might be an echocardiographic marker of DCM both in the presence and absence of critical coronary artery disease.