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The relationship between epicardial fat tissue (EFT) and left ventricular (LV) dysfunction, cardiovascular metabolism, and coronary artery disease is well known. The objective of this study was to evaluate EFT in patients with chronic obstructive pulmonary disease (COPD) who also have right ventricular systolic dysfunction (RVSD).
This observational study was comprised of 98 patients with COPD and 40 healthy controls, who were divided into groups according to fractional area changes (FACs) in order to evaluate right ventricular functions. Subgroup analysis was performed according to degree of RVSD in the patients with COPD (RVFAC<17%, 25-31%, or 32-60%). Statistical analysis was performed using Student's t-test, the Mann-Whitney U test, and a chi-square test along with the Kruskal-Wallis one-way analysis of variance (ANOVA) and one-way ANOVA post-hoc tests.
The EFT decreased in the patients with COPD compared with the control group (4.92±1.2 versus 6.35±1.1, respectively; p=0.001), and the mean EFT was 4.1±0.77 mm in patients with severe RVSD and 5.48±1.28 mm in patients with mild RVSD (p <0.001). The difference among the three groups was independent of body mass index (BMI).
Our data points to the fact that the EFT decreases in patients with COPD who have RVSD and that it is also a predictor for the degree of RVSD.
|COPD (n=98)||CONTROL (n=40)||*p|
|Diabetes, n (%)||4 (4%)||0||0.195|
|Dyslipidemia, n (%)||4 (4%)||4(%10)||0.177|
|Hypertension, n (%)||4 (4%)||0||0.195|
|Smokers, n (%)||57(%58)||9(%22)||0.001|
COPD= Chronic pulmonary obstructive disease, BMI= Body mass index, MPI= Myocardial performance index, IVA= Isovolumic acceleration time,TAPSE= Tricuspid annular plane systolic excursion, EFT= Epicardial fat tissue, sPAP= Systolic pulmonary arterial pressure, NS: nonsignificant *Chi-square test and Student's t-test
|SEVERE RVSD (RVFAC<17%) (n=40)||MİLD RVSD (RVFAC 25-31%) (n=58)||CONTROL (RVFAC 32-60%) (n=40)||*p|
|Diabetes, n (%)||2 (5%)||2 (3.4%)||0||0.39|
|Dyslipidemia, n (%)||0||4 (6.8%)||4 (10%)||0.14|
|Hypertension, n (%)||14 (35%)||29 (50%)||19 (47%)||0.22|
|Smokers, n (%)||22 (55%)||35 (60%)||9 (22.5%)||0.01|
RVSD= Right ventricular systolic dysfunction, RVFAC= Right ventricular fractional area change, BMI= Body mass index, MPI= Myocardial performance index, IVA= Isovolumic acceleration time,TAPSE= Tricuspid annular plane systolic excursion, EFT= Epicardial fat tissue, sPAP= Systolic pulmonary arterial pressure, NS: nonsignificant Data is expressed as mean±SD and median (minimum-maximum) values,* ANOVA followed by Tukey's honestly significant difference (HSD) post-hoc test