Author + information
- Huseyin Altug Cakmak1,
- Hasan Ali Barman1,
- Baris Ikitimur1,
- Ender Coskunpinar2,
- Yasemin Musteri Oltulu2,
- Gunay Can3,
- Bilgehan Karadag1,
- Servet Altay4 and
- Vural Ali Vural1
Recent studies have demonstrated the potential role of microRNAs (miRNA) as biomarkers in various cardiovascular disorders. Left ventricle hypertrophy and dilatation are among changes encountered in the remodeling process in patients with congestive heart failure (CHF).
The aim of this study was to investigate the relationship between expression levels of dysregulated miRNAs and echocardiographic parameters related with left ventricular mass index in chronic CHF patients.
In our study, 20 clinically stable (NYHA II) and 22 decompensated (NYHA III and IV) systolic CHF (ejection fraction (EF) <%40) cases were enrolled. Whole genome miRNA profiling was done with microarray method and dysregulated miRNAs were detected compared to 15 healthy controls. All patients underwent trans-thoracic echocardiography in order to determine left ventricular EF, dimensions, left ventricular mass index (LVMI) and tissue doppler peak systolic velocity of mitral annulus values.
A total of 29 miRNAs were up or down regulated in CHF patients. Out of these 29 miRNAs, five were demonstrated to be correlated with LVMI values. Specifically, miR-182 (p=0.04), miR-200a-star (p=0.019), and miR-568 (p=0.023) were found to be negatively correlated with LVMI. On the other hand, mir-155 (p=0.019), and miR-595 (p=0.04) were positively correlated with LVMI in patients with CHF. There was no relation between expression levels of dysregulated miRNAs and following echocardiographic parameters: EF (p>0.05) and tissue doppler peak systolic velocity of mitral annulus (p>0.05).
This study demonstrates the significant relationship between some, but not all of the dysregulated miRNAs and left ventricular mass index values in systolic CHF patients.