Author + information
- Hakan Uçar,
- Mustafa Gür,
- Taner Şeker,
- Caner Türkoğlu,
- Onur Kaypaklı,
- Durmuş Yıldıray Şahin,
- Zafer Elbasan and
- Murat Çaylı
The high-sensitivity cardiac troponin T (hs-cTnT) assay provides important prognostic information in cardiovascular diseases. Although hs-cTnT is associated with left ventricle (LV) hypertrophy, hs-cTnT levels have not been investigated in different LV geometric patterns incorporating normal LV structure and concentric remodelling in addition to LV hypertrophy.
We aimed to investigate the possible association between hs-cTnT and LV geometric patterns in newly diagnosed hypertensive patients.
We studied 306 patients with newly diagnosed HT (mean age 51.7 ± 5.4 years) and 44 healthy control subjects (mean age 51.2 ± 5.1 years). Echocardiographic examination was performed in all subjects. Four different geometric patterns were determined in hypertensive patients according to LV mass index (LVMI) and relative wall thickness (RWT). Hs-cTnT and other biochemical markers were measured in all participants.
The highest hs-cTnT values were observed in concentric hypertrophy group compared with control, normal geometry, concentric remodelling and eccentric hypertrophy groups (p<0.05, for all). Also, hs-cTnT values of eccentric hypertrophy group were higher than control, normal geometry and concentric remodelling groups (p<0.05, for all). Multivariate regression analysis showed that hs-cTnT was independently associated with LV geometry (β=0.326, p=0.001) as well as LVMI (β=0.228, p=0.010) and creatinin level(β=.0.132, p=0.012).
Hs-cTnT levels related with not only LV hypertrophy but also LV geometry in hypertensive patients. Hs-cTnT levels may mediate poor prognosis in hypertensive patients including different LV geometric patterns.
|Variables||Control Group||NG Group||CR Group||EH Group||CH group||P value|
|Gender (male)||20 (45.5%)||40 (46.0%)||33 (45.8%)||21 (37.5%)||42 (46.2%)||0.852∞|
|Hs-Troponin T, pg/ml||4.46±1.0||4.72±1.3||5.0±2.1||6.0±2.7||9.5±3.3||<0.001|