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Low HDL cholesterol (HDL-C) levels are now recognized as an independent cardiovascular risk factor and comprise part of the metabolic syndrome. Low testosterone (T) levels are a common finding in men with coronary artery disease.
The relationship between endogenous plasma testosterone and high-density lipoprotein cholesterol (HDL-C) was assessed among 933 men (27-74) years old originally recruited for an cross-sectional study of endogenous testosterone and coronary artery disease (CAD). Patients underwent coronarygraphy and at the same time, serial testosterone was measured, triglycerides, total-and HDL-cholesterol.
Patients (coronary narrowing >50% n = 689) were compared to those without significant stenoses (n = 244). High-density lipoprotein cholesterol (HDLC) and triglyceride were both significantly associated with the presence of CAD (p<0.05). Testosterone (mean 5.568±2.109 nmol/l range 0.106 – 14.108 nmol/l) correlated directly with HDL-cholesterol (r=0. 0.358, < P=0.0500) and inversely with triglycerides (r=-0.069, p<0.0010),but not with LDL-cholesterol (r=0.140, p=0.1990) total cholesterol (r=-0.036, p<0.820),
These findings suggest the positive association between levels of testosterone and HDL cholesterol, The negative association between levels of testosterone triglyceride.