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Low circulating levels of high density lipoprotein-cholesterol (HDL-C) is the most common form of dyslipidemia in coronary heart disease (CHD). In previous studies, it has been shown that low circulating levels of HDL-C is a strong, independent risk factor for premature atherosclerosis and CHD. Plasma HDL-C particles exert potent anti-atherogenic and anti-inflammatory activities in addition to antioxidant activity. Thus, we aimed to investigate biochemical parameters associated with oxidative stress stress in low HDL-C.
This study included 33 consecutive patients with low HDL-C (≤35 mg/dl) (18 male, age 55±13 years) and 33 age and sex-matched control subjects with normal HDL-C (>35 mg/dl) (17 male, mean age 58±13 years). We evaluated clinical parameters and laboratory parameters which are associated with oxidative stress such as total oxidative status (TOS), total antioxidant capacity (TAC), oxidative stress index (OSI), uric asit, gamma glutamyl transferase (GGT) and alkaline phosphatase (ALP).
Groups were comparable in demographic and clinic characteristics. Except for ALT levels routine laboratory tests were similar in both groups. ALT levels was higher in low HDL-C patients than in subjects with normal HDL-C (29±19 vs 18±5.3 mg/dl, p<0.01). Triglyceride (TG) levels were higher in low HDL-C group, total cholesterol (TK) and low density lipoprotein (LDL) levels were significantly higher in control group. HDL-C levels was lower in patients group than in control group (30±3 vs 48±7 mg/dl, p<0.01). Uric asit (6.3±1.5 vs 4.5±1.3, respectively p<0.01) and GGT levels [35 (10-122) vs 23 (11-71.6), p=0.02] were significantly higher in low HDL-C group than in control group. TOS levels were significantly higher in low HDL-C group than in control group [2.95 (0.01-7.26) vs 1.17 (0.80-1.80), p<0.01], TAC levels were significantly lower in low HDL-C group than in control group [1.15 (0.08-2.25) vs 1.99 (0.42-6.21), p<0.01]. OSI levels [474 (1.19-5050) vs 176 (28-597), p=0.06] were slightly higher in HDL-C group although it is not significant.
Our findings show that oxidative stress levels increase in patients with low HDL-C. From this aspect, treatments that increase HDL levels or improve the antioxidant status in low HDL-C patients might be reasonable to slow down the process of oxidative stress. However, this result needs to be validated in large-sized studies.