Author + information
- Murtaza Emre Durakoğlugil1,
- Teslime Ayaz2,
- Sinan Altan Kocaman3,
- Aynur Kırbaş4,
- Tuğba Durakoğlugil5,
- Turan Erdoğan1,
- Mustafa Çetin3,
- Osman Zikrullah Şahin2 and
- Yüksel Çiçek1
Catestatin (CST), a novel peptide derived from Chromogranin A, has diverse cardiovascular actions in addition to diminished sympathoadrenal flow. We intended to investigate metabolic and vascular associations of CST.
We evaluated plasma catestatin, lipid parameters, left ventricular mass, carotid intima-media thickness (CIMT) and flow-mediated dilation (FMD) of brachial artery in a group of 109 consecutive untreated hypertensive patients.
Catestatin levels were significantly higher in females. Among all study parameters age (r=0.280, p=0.001), high density lipoprotein (HDL) (r=0.426, p<0.001) positively whereas triglycerides (r=-0.317, p=0.002), hemoglobin (r=-0.273, p=0.010), and left ventricular mass (r=-0.230, p=0.034) negatively correlated to plasma catestatin. We could not detect an association between vascular parameters and catestatin. We also documented increased CST concentrations in previously untreated hypertensive patients compared to healthy controls (2.27 vs. 1.92 ng/ml, p=0.004). Multiple linear regression analysis revealed age (Beta: 0.201, p=0.041) and HDL cholesterol (Beta: 0.390, p<0.001) as independent correlates of plasma catestatin concentration.
We documented that catestatin is correlated with high density lipoprotein concentrations among several metabolic, vascular and biochemical parameters, in previously untreated hypertensive patients. The physiology and clinical significance of this association remains unknown and requires further studies to be identified.
|Linear regression analysis||Dependent variable: Plasma catestatin level||Beta (standardized)||†P value||Beta (standardized)|
|Independent variables||*P value|
|Left ventricular mass (g)||0.189||-0.147|
Linear regression analysis with enter method was used for all relevant independent variables which were included if they were significantly different in the univariate analyses*. In addition the analysis was repeated after a pre-elimination with Stepwise method for the independent variables†.