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Coronary artery disease (CAD) is a chronic process that begins early in life and progresses silently before becoming symptomatic. Besides scientifically based medical treatment of this disease, patients frequently make use of alternative medicine. The product sold as Clavis Panax that used by many people as a food supplements according to the advertisements. Intake of a mixture of plant extracts may have serious consequences in humans as drug interactions and side effects are unknown. Herein, we report the case of a 58-year-old man who presented with chest pain. Due to typical symptoms a coronary angiography and stent implantation was performed to the critical lesions at the left anterior descending artery and right coronary artery successfully. Initially his LDL level was 87 mg/dL, total cholesterol level was 154 mg/dL and triglyceride level was 165 mg/dL. Three months later after he was discharged, he gave up his medication and started to take an herbal drug called Clavis Panax. At the sixth month after stent implantation, his LDL level was 224 mg/dL, total cholesterol was 388 mg/dL and triglyceride was 365 mg/dL. He was warned to stop taking Clavis and was prescribed an increased dose of statin but he refused. He died of a myocardial infarction in the eighth month after stent implantation.